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Fifty-seven patients with epilepsy treated for a minimum of one year with either phenytoin (n = 28) or carbamazepine (n = 29) were evaluated clinically and radiologically using standard methods. No significant differences in sex, age, antiepileptic therapy, seizure patterns or disease severity were demonstrated between groups. The overall frequency of skeletal changes was significantly greater in the patients receiving phenytoin. A comparative assessment of the skeletal changes with each drug revealed that patients treated with phenytoin demonstrated a significantly higher frequency of hip (26 versus 3%) and neck-shaft angles (48 versus 9%) than those on carb 0b46394aab